	Priority claims
#	Publication number	Publication date	1	2	3	4	5
1	AU PR409401 D0	Apr 26, 2001	X
2	AU 2002245934 B2	May 1, 2008	X	X	X
3	CA 2442495 A1	Oct 10, 2002	X	X
4	EP 1385874 A1	Feb 4, 2004	X	X
5	EP 1385874 A4	Sep 29, 2004	X	X
6	JP 2005500017 T	Jan 6, 2005	X	X
7	US 2005/0215480 A1	Sep 29, 2005	X	X
8	US 7348400 B2	Mar 25, 2008	X	X
9	US 2009/0197810 A1	Aug 6, 2009	X	X		X	X
10	WO 2002/079236 A1	Oct 10, 2002	X

#	Application number	Application date
1	AU PR409401 A	Mar 29, 2001
2	PCT/AU 0200411	Mar 28, 2002
3	AU 2002245934 A	Mar 28, 2002
4	US 2008/054212 A	Mar 24, 2008
5	US 2004/473246 A	Aug 26, 2004

Summary

Application number	AU PR409401 A
Publication number	AU PR409401 D0
Application date	--
Publication date	Apr 26, 2001

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001

Classifications

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Abstract

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2. AU 2002245934 B2 : Alpha conotoxin peptides with analgesic properties

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Summary

Title	Alpha conotoxin peptides with analgesic properties
Application number	AU 2002245934 A
Publication number	AU 2002245934 B2
Application date	Mar 28, 2002
Publication date	May 1, 2008
Applicants	LIVETT BRUCE; KHALIL ZEINAB; GAYLER KENWYN; DOWN JOHN; SANDALL DAVID; KEAYS DAVID
Inventors	KHALIL ZEINAB; LIVETT BRUCE; KEAYS DAVID; SANDALL DAVID; GAYLER KENWYN; DOWN JOHN

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002
AU 2002245934 A	Mar 28, 2002

Classifications

IPCR	A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

IPCR

A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

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Legal events

Gazette date	Document number	Legal code	Description
Aug 28, 2008	AU 2002245934 A	FGA	+LETTERS PATENT SEALED (STANDARD PATENT)

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3. CA 2442495 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIESALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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Summary

Title	ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIESALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES
Application number	CA 2442495 A
Publication number	CA 2442495 A1
Application date	Mar 28, 2002
Publication date	Oct 10, 2002
Applicants	LIVETT BRUCE [AU]; KEAYS DAVID ANTHONY [GB]; SANDALL DAVID WILLIAM [AU]; DOWN JOHN [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN [AU]
Inventors	LIVETT BRUCE [AU]; GAYLER KENWYN [AU]; DOWN JOHN [AU]; KEAYS DAVID ANTHONY [GB]; SANDALL DAVID WILLIAM [AU]; KHALIL ZEINAB [AU]

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002

Classifications

EPC	C07K14/435A
IPC	A61K38/10; A61P21/00; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/28; A61P25/34; A61P29/00; C07K7/08
IPCR	A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

This invention relates to novel .alpha.-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C-NH2 in which Xaa1 is G or D Xaa3 is proline, hydroxyproline or glutamine each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid Xaa9 is proline, hydroxyproline or glutamine Xaa10 is aspartate, glutamate or .gamma.-carboxyglutamate Xaa11 is optionally absent and the C-terminus is optionally amidated, with the proviso that the peptide is not .alpha.-conotoxin Ep1 or .alpha.-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.

Legal events

Gazette date	Document number	Legal code	Description
Sep 29, 2003	CA 2442495 A	AFNE	+NATIONAL PHASE ENTRY
Mar 20, 2007	CA 2442495 A	EEER	+EXAMINATION REQUEST
May 24, 2010	CA 2442495 A	FZDE	-DEAD Effective DATE 20100329

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4. EP 1385874 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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Summary

Title	ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES
Application number	EP 2002/713927 A
Publication number	EP 1385874 A1
Application date	Mar 28, 2002
Publication date	Feb 4, 2004
Applicants	LIVETT BRUCE [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN [AU]; SANDALL DAVID WILLIAM [AU]; DOWN, JOHN,; KEAYS, DAVID ANTHONY
Inventors	LIVETT BRUCE [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN [AU]; DOWN JOHN [AU]; SANDALL DAVID WILLIAM [AU]; KEAYS DAVID ANTHONY [GB]

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002

Classifications

EPC	C07K14/435A
IPC	A61K38/10; A61P21/00; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/28; A61P25/34; A61P29/00; C07K7/08
IPCR	A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

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Legal events

Gazette date	Document number	Legal code	Description
Feb 4, 2004	EP 02713927 A	17P	+REQUEST FOR EXAMINATION FILED Effective DATE 20031028
Feb 4, 2004	EP 02713927 A	AK	+DESIGNATED CONTRACTING STATES: Kind Code of Ref Document A1 +DESIGNATED CONTRACTING STATES: Designated State(s) AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Feb 4, 2004	EP 02713927 A	AX	+EXTENSION OF THE EUROPEAN PATENT TO Countries concerned AL LT LV MK RO SI
Aug 11, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name LIVETT, BRUCE
Aug 11, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name KHALIL, ZEINAB
Aug 11, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name GAYLER, KENWYN
Aug 11, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name DOWN, JOHN
Aug 11, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name SANDALL, DAVID WILLIAM
Aug 11, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name LIVETT, BRUCE
Aug 11, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name KHALIL, ZEINAB
Aug 11, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name GAYLER, KENWYN
Aug 11, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name DOWN, JOHN
Aug 11, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name SANDALL, DAVID WILLIAM
Sep 22, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name LIVETT, BRUCE
Sep 22, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name KHALIL, ZEINAB
Sep 22, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name GAYLER, KENWYN
Sep 22, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name DOWN, JOHN
Sep 22, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name SANDALL, DAVID WILLIAM
Sep 22, 2004	EP 02713927 A	RAP1	TRANSFER OF RIGHTS OF AN EP APPLICATION Owner Name KEAYS, DAVID ANTHONY
Sep 22, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name LIVETT, BRUCE
Sep 22, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name KHALIL, ZEINAB
Sep 22, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name GAYLER, KENWYN
Sep 22, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name DOWN, JOHN
Sep 22, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name SANDALL, DAVID WILLIAM
Sep 22, 2004	EP 02713927 A	RIN1	INVENTOR (CORRECTION) Inventor Name KEAYS, DAVID ANTHONY
Sep 29, 2004	EP 02713927 A	A4	+SUPPLEMENTARY SEARCH REPORT Effective DATE 20040812
Apr 7, 2010	EP 02713927 A	18D	-DEEMED TO BE WITHDRAWN Effective DATE 20091001

5. EP 1385874 A4 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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Summary

Title	ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES
Application number	EP 2002/713927 A
Publication number	EP 1385874 A4
Application date	Mar 28, 2002
Publication date	Sep 29, 2004
Applicants	LIVETT BRUCE [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN [AU]; DOWN JOHN [AU]; SANDALL DAVID WILLIAM [AU]; KEAYS DAVID ANTHONY [GB]
Inventors	LIVETT BRUCE [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN [AU]; DOWN JOHN [AU]; SANDALL DAVID WILLIAM [AU]; KEAYS DAVID ANTHONY [GB]

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002

Classifications

EPC	C07K14/435A
IPC	A61K38/10; A61P21/00; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/28; A61P25/34; A61P29/00; C07K7/08
IPCR	A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

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6. JP 2005500017 T

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Summary

Application number	JP 2002577860 T
Publication number	JP 2005500017 T
Application date	Mar 28, 2002
Publication date	Jan 6, 2005

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002

Classifications

EPC	C07K14/435A
IPC	A61K38/00; A61P1/02; A61P17/02; A61P19/02; A61P25/02; A61P25/04; A61P25/08; A61P25/16; A61P25/28; A61P25/34; A61P29/00; A61P35/00; A61P43/00; C07K14/435; C12N15/09
IPCR	A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

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Legal events

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7. US 2005/0215480 A1 : Alpha conotoxin peptides with analgesic properties

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Summary

Title	Alpha conotoxin peptides with analgesic properties
Application number	US 2004/473246 A
Publication number	US 2005/0215480 A1
Application date	Aug 26, 2004
Publication date	Sep 29, 2005
Inventors	LIVETT BRUCE G [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN R [AU]; DOWN JOHN G [AU]; SANDALL DAVID W [AU]; KEAYS DAVID A [GB]; LIVETT BRUCE GRAYSON,; GAYLER KENWYN RONALD,; DOWN JOHN GEOFFREY,; SANDALL DAVID WILLIAM,; KEAYS DAVID ANTHONY

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002

Classifications

EPC	C07K14/435A
IPC	A61K38/10; C07K14/435; C07K7/08
IPCR	A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

This invention relates to novel alpha-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C-NH2 in which Xaa1 is G or D Xaa3 is proline, hydroxyproline or glutamine each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid Xaa9 is proline, hydroxyproline or glutamine Xaa10 is aspartate, glutamate or gamma-carboxyglutamate Xaa11 is optionally absent and the C-terminus is optionally amidated, with the proviso that the peptide is not alpha-conotoxin Ep1 or alpha-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.

Legal events

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8. US 7348400 B2 : alpha-conotoxin peptides with analgesic properties

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Summary

Title	alpha-conotoxin peptides with analgesic properties
Application number	US 2004/473246 A
Publication number	US 7348400 B2
Application date	Aug 26, 2004
Publication date	Mar 25, 2008
Inventors	LIVETT BRUCE GRAYSON [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN RONALD [AU]; DOWN JOHN GEOFFREY [AU]; SANDALL DAVID WILLIAM [AU]; KEAYS DAVID ANTHONY [GB]; LIVETT BRUCE GRAYSON,; GAYLER KENWYN RONALD,; DOWN JOHN GEOFFREY,; SANDALL DAVID WILLIAM,; KEAYS DAVID ANTHONY

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002

Classifications

EPC

C07K14/435A

IPCR

A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 7/ 00 A I; C07K 7/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

This invention relates to novel alpha-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C-NH2 in which Xaa1 is G or D Xaa3 is proline, hydroxyproline or glutamine each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid Xaa9 is proline, hydroxyproline or glutamine Xaa10 is aspartate, glutamate or gamma-carboxyglutamate Xaa11 is optionally absent and the C-terminus is optionally amidated, with the proviso that the peptide is not alpha-conotoxin Ep1 or alpha-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.

Legal events

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9. US 2009/0197810 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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Summary

Title	ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES
Application number	US 2008/054212 A
Publication number	US 2009/0197810 A1
Application date	Mar 24, 2008
Publication date	Aug 6, 2009
Inventors	LIVETT BRUCE GRAYSON [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN RONALD [AU]; DOWN JOHN GEOFFREY [AU]; SANDALL DAVID WILLIAM [AU]; KEAYS DAVID ANTHONY [GB]

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001
PCT/AU 0200411	Mar 28, 2002
US 2008/054212 A	Mar 24, 2008
US 2004/473246 A	Aug 26, 2004

Classifications

EPC

C07K14/435A

IPCR

A61K 38/ 00 A I; A61K 38/ 00 C I; A61K 38/ 10 A I; A61K 38/ 10 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

This invention relates to novel alpha-conotoxin-like peptides comprising the following amino acid sequence (SEQ ID NO:10): Xaa1-Cys-Cys-Ser-Xaa2-Xaa3-Xaa4-Cys-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Cys-NH2 in which Xaa1 is Gly or Asp Xaa3 is Pro, Hyp or Glu each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid Xaa9 is Pro, Hyp or Glu Xaa10 is Asp, Glu or gamma-carboxyGlu Xaa11 is optionally absent and the C-terminus is optionally amidated, with the proviso that the peptide is not alpha-conotoxin Ep1 or alpha-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.

Legal events

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10. WO 2002/079236 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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Summary

Title	ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES
Application number	PCT/AU 0200411
Publication number	WO 2002/079236 A1
Application date	Mar 28, 2002
Publication date	Oct 10, 2002
Applicants	LIVETT BRUCE [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN [AU]; DOWN JOHN [AU]
Inventors	LIVETT BRUCE [AU]; KHALIL ZEINAB [AU]; GAYLER KENWYN [AU]; DOWN JOHN [AU]

Priorities

Application number	Application date
AU PR409401 A	Mar 29, 2001

Classifications

EPC	C07K14/435A
IPC	A61K38/10; A61P21/00; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/28; A61P25/34; A61P29/00; C07K7/08
IPCR	A61K 38/ 00 A I; A61K 38/ 00 C I; A61P 1/ 00 C I; A61P 1/ 02 A I; A61P 17/ 00 C I; A61P 17/ 02 A I; A61P 19/ 00 C I; A61P 19/ 02 A I; A61P 21/ 00 A I; A61P 21/ 00 C I; A61P 25/ 00 A I; A61P 25/ 00 C I; A61P 25/ 02 A I; A61P 25/ 04 A I; A61P 25/ 08 A I; A61P 25/ 16 A I; A61P 25/ 28 A I; A61P 25/ 34 A I; A61P 29/ 00 A I; A61P 29/ 00 C I; A61P 35/ 00 A I; A61P 35/ 00 C I; A61P 43/ 00 A I; A61P 43/ 00 C I; C07K 14/ 435 A I; C07K 14/ 435 C I; C12N 15/ 09 A I; C12N 15/ 09 C I

Abstract

This invention relates to novel alpha -conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C-NH2 in which Xaa1 is G or D Xaa3 is proline, hydroxyproline or glutamine each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid Xaa9 is proline, hydroxyproline or glutamine Xaa10 is aspartate, glutamate or gamma -carboxyglutamate Xaa11 is optionally absent and the C-terminus is optionally amidated, with the proviso that the peptide is not alpha -conotoxin Ep1 or alpha -conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.

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1. AU PR409401 D0

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2. AU 2002245934 B2 : Alpha conotoxin peptides with analgesic properties

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3. CA 2442495 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIESALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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4. EP 1385874 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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5. EP 1385874 A4 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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6. JP 2005500017 T

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7. US 2005/0215480 A1 : Alpha conotoxin peptides with analgesic properties

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8. US 7348400 B2 : alpha-conotoxin peptides with analgesic properties

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9. US 2009/0197810 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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10. WO 2002/079236 A1 : ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES

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